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KMID : 0363220130510120933
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Korean Journal of Dermatology
2013 Volume.51 No. 12 p.933 ~ p.938
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A Clinical Study of Chemotherapy-Induced Permanent Alopecia
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Jung Mi-Young
Lee Dong-Youn
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Abstract
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Background: Anagen Effluvium is one of the typical side effects of chemotherapy, which is completely reversible.
However, there are growing numbers of chemotherapy-induced permanent alopecia (CIPAL) which are characterizedby an absence of or an incomplete hair regrowth 6-months beyond the cessation of chemotherapy.
Objective: The purpose of this study is to reveal the clinical characteristics of CIPAL patients.
Methods: We retrospectively included 54 cases with CIPAL whom are being diagnosed from January 1996 toDecember 2011. The age, gender, duration of alopecia, familial history of alopecia, past medical history (includingthe types of chemotherapy agents), clinical patterns of alopecia and treatment responses were all analyzed.
Results: There was no sexual predominance. Mean age of the onset was 31.5 years old. There were two morphologicaltypes of CIPAL: diffused (69%) and androgenetic patterned (31%). Cyclophosphamide is the most commonlyused chemotherapy agent in both types of alopecia. The response to treatment with topical minoxidil and/ororal finasteride was rather restrictive.
Conclusion: In some cases of hair loss due to chemotherapic agents, the hair regrowths after the cessation ofchemotherapy are rather restricted. This study demonstrated the clinical features of CIPAL. The patterns of CIPALare either diffused or androgenetic. Thus, it is necessary to consider the possibilities of permanent alopecia whichmay occur after chemotherapy.
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KEYWORD
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Chemotherapy-induced permanent alopecia, CIPAL
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